We welcome you to discuss the latest evidence in the field of cellular senescence at the Biomedical Research Foundation of the Academy of Athens.
The involvement of senescent cells in both physiological and pathological contexts highlights the double-edged sword nature of senescence. Temporal induction of cellular senescence during embryonic development or normal adult life is linked with beneficial properties. Conversely, on a chronic basis senescence can endorse detrimental effects linked with pathological conditions and aging. Understanding this dual face of cellular senescence is rapidly expanding, while new therapeutic strategies are evolving.
DNA damage and repair, genomic instability, telomeres, chromatin, protein instability, autophagy/metabolism, immunosenescence, SASP, microenvironment, ageing, age-related diseases, cancer, senolytics/senotherapeutics.